Fresh analysis suggests that individuals who come off blockbuster slimming jabs like semaglutide or tirzepatide may regain lost weight far faster than those who stop conventional lifestyle plans.
Findings released in a leading medical journal shows that while obese individuals can lose a large proportion of their body weight while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month once they quit.
"Individuals using these medications should be informed of the risk of fast rebound weight gain when the treatment is stopped," warns lead investigator Dr. Susan Jebb.
This pace of regain means a reversion to starting mass in about a year and a half.
Comparing Therapies
The research, which reviewed 37 of studies involving over 9,000 of patients, compared the results of these new drugs with other pills.
Researchers note that individuals who lose weight through dieting typically experience a slower creep back—around 100 grams monthly—after stopping.
The Reason for the Rapid Rebound
Experts suggest the mechanism of the jabs accounts for the heightened weight return.
The injections mimic a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 concentrations several times higher than the body's typical production might result in the body to produce less of its own natural hormone, and could diminish responsiveness to its effects," noted Dr. Adam Collins, a nutrition expert.
"Discontinuation of this hormone supplement results in appetite is unsuppressed, making excessive eating far more likely."
A Chronic Condition?
Medical guidelines advise the jabs for individuals with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts contend that, given the likelihood of relapse, the therapy might need to be ongoing.
This perspective is echoed by pharmaceutical companies, who note that the results "underscore the persistent nature of obesity," comparing it to managing conditions like high blood pressure.
User Accounts
Individuals who have discontinued the jabs report a sudden resurgence of cravings.
"It was like a trigger that goes on and I was suddenly starving," said an individual.
The struggle is worsened if users have not established sustainable lifestyle or habit modifications during therapy.
Widespread Interest
Figures show that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with interest remaining high.
- Adoption is greater among women compared to men.
- The middle-aged age group shows the highest usage rates.
- A large proportion obtain the drugs through private prescriptions rather than public health services.
In conclusion, researchers caution that while the jabs are powerful tools for shedding pounds, they are not a permanent cure and lasting health benefits likely depends on combined lifestyle management.
